Volasertib is an extremely potent and selective inhibitor (IC50’s: Plk1= 0.87 nM, Plk2 = 5 nM, Plk3 = 56 nM) of Polo-like kinase , a critical controller of multiple essential steps of mitosis. It has shown efficacy in multiple solid xenograft tumors models and in clinical studies in patients...
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Volasertib is an extremely potent and selective inhibitor (IC50’s: Plk1= 0.87 nM, Plk2 = 5 nM, Plk3 = 56 nM) of Polo-like kinase , a critical controller of multiple essential steps of mitosis. It has shown efficacy in multiple solid xenograft tumors models and in clinical studies in patients with acute myeloid leukemia. Volasertib has also been shown to potently inhibit BRD4 (Kd = 79 nM, IC50’s bromodomains 1 and 2 of BRD4 = 300 and 770 nM respectively)
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