Immunomodulator. Inhibits secretion of IL-1β, TNF-α, and IL-10 from murine macrophages stimulated with LPS and spares T cell function. Ameliorates the course of acute and chronic immunoinflammatory conditions such as carrageenan-induced pleurisy, LPS-induced lethality and type II...
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Immunomodulator. Inhibits secretion of IL-1β, TNF-α, and IL-10 from murine macrophages stimulated with LPS and spares T cell function. Ameliorates the course of acute and chronic immunoinflammatory conditions such as carrageenan-induced pleurisy, LPS-induced lethality and type II collagen-induced arthritis in mouse models. Prevents spontaneous and accelerated forms of autoimmune diabetes in a NOD mouse model. Moldulates genes involved in LPS-induced Toll-like receptor 4 activation in a mouse Lupus model. Displays protective effects in particulate matter-induced acute lung injury by blocking TLR4 signaling
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