STF31 is an inhibitor of glucose transporter 1 (GLUT1; IC50 = 1 µM) and NAMPT3. Inhibition of glucose transporters to target It has been shown to kill renal cell carcinoma cells (the majority of which lack the von Hippel-Lindau suppressor gene) without toxicity to normal cells. The target of...
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STF31 is an inhibitor of glucose transporter 1 (GLUT1; IC50 = 1 µM) and NAMPT3. Inhibition of glucose transporters to target It has been shown to kill renal cell carcinoma cells (the majority of which lack the von Hippel-Lindau suppressor gene) without toxicity to normal cells. The target of STF31 anti-tumor activity has recently been questioned via use of large-scale cancer cell-line profiling. This profiling indicated that nicotinamide phosphoribosyltransferase (NAMPT) was in fact the target of STF31. The inhibition of NAMPT by STF31 was confirmed via biochemical assay against recombinant NAMPT. The ability of STF31 to inhibit NAMPT had been previously displayed (IC50 = 19 nM)
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NAMPT identifies nicotinamide phosphoribosyltransferase in Homo sapiens (Human). This target record connects NCBI Gene 10135, UniProtKB P43490 and related ABMIUM catalogue products.
