Manufactured by:TriBio Science
RUO

Sphingosine, PKC inhibitor

Endogenous sphingolipid found in cells esterified as phosphatidylcholine (sphingomyelin) and released by the action of sphingomyelinases. Potent and selective inhibitor of protein kinase C (IC50=1-3 µM). Inhibition is competitive with DAG, phorbol esters and Ca2+. May be phosphorylated by...

SKU:
ABM148765-1
Manufacturer SKU
TBI2287-100MG | TBI2287-20MG
Product type
Biochemical Inhibitors
TargetPKC
Purity>98%

Manufacturer provenance

Manufactured by:
TriBio Science
Sold by:
ABMIUM
Fulfilled from:
Manufacturer facility or confirmed fulfilment location

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Product description

Endogenous sphingolipid found in cells esterified as phosphatidylcholine (sphingomyelin) and released by the action of sphingomyelinases. Potent and selective inhibitor of protein kinase C (IC50=1-3 µM). Inhibition is competitive with DAG, phorbol esters and Ca2+. May be phosphorylated by sphingosine kinases producing sphingosine-1-phosphate, a bioactive lipid producing a plethora of biological effects

Key facts & specifications
Also known as
D(+)-erythro-1,3-Dihydroxy-2-amino-4-trans-octadecene
Molecular weight
299.50
Form / buffer
powder
Activity
Endogenous sphingolipid found in cells esterified as phosphatidylcholine (sphingomyelin) and released by the action of sphingomyelinases. Potent and selective inhibitor of protein kinase C (IC50=1-3 µM). Inhibition is competitive with DAG, phorbol esters and Ca2+. May be phosphorylated by sphingosine kinases producing sphingosine-1-phosphate, a bioactive lipid producing a plethora of biological effects.
Molecular formula
C 18 H 37 NO 2
Solubility
Soluble in DMSO (up to 25 mg/ml with warming) or in Ethanol (up to 25 mg/ml with warming).
Technical note
Stability: ≥ 1 year.
Identifiers & database references
Manufacturer SKU
TBI2287-100MG | TBI2287-20MG
CAS number
123-78-4
Storage, stability & shipping
Storage conditions
-20°C
Shipped at
4°C
Long-term storage
-20°C
Compliance & documents
Datasheet
Open datasheet
Frequently asked questions
Who manufactured this product?

This product is manufactured by TriBio Science and sold through ABMIUM without relabelling.

Can ABMIUM ship this product internationally?

ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.

Can I check suitability before ordering?

Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.

Is this product for clinical use?

Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.

TriBio Science
£343.00