Inhibits the p53-MDM2 interaction (20 μM). Alkylates one catalytic histidine residue (His-397) participating in the charge-relay system of carboxypeptidase Y. Has also been shown to inhibit bovine chymotrypsin A-γ. A potent inhibitor of the severe acute respiratory syndrome coronavirus...
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Inhibits the p53-MDM2 interaction (20 μM). Alkylates one catalytic histidine residue (His-397) participating in the charge-relay system of carboxypeptidase Y. Has also been shown to inhibit bovine chymotrypsin A-γ. A potent inhibitor of the severe acute respiratory syndrome coronavirus (SARS-CoV) main protease (Mpro), Ki=306 nM
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