An inhibitor of receptor-mediated calcium entry (RMCE) with IC50‘s of 8.5 μM for ADP stimulated platelets and 11.7 μM for thrombin stimulated platelets. Also inhibits Voltage-gated Ca 2+ but not ATP-gated Ca 2+ entry. It has also been shown to block transient receptor potential canonical type...
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An inhibitor of receptor-mediated calcium entry (RMCE) with IC50‘s of 8.5 μM for ADP stimulated platelets and 11.7 μM for thrombin stimulated platelets. Also inhibits Voltage-gated Ca 2+ but not ATP-gated Ca 2+ entry. It has also been shown to block transient receptor potential canonical type (TRPC) channels, high-voltage-activated (HVA) L-type channels, K channels, sarcoplasmic reticulum Ca-ATPase and voltage-gated sodium channels. SKF-96365 is a potent blocker of LVA T-type Ca channels, in particular Ca(V)3.1 (IC50 = 0.56 μM)
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