The most common member of the rotenoid natural product family inhibits complex I of the mitochondrial electron transport chain (IC 50 = 1.7 – 2.2 μM). Also inhibits NADH oxidation by cardiac sarcoplasmic reticulum (IC 50 = 3.4 nM). May be used to induce Parkinsonism in animal models. Inhibits...
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The most common member of the rotenoid natural product family inhibits complex I of the mitochondrial electron transport chain (IC 50 = 1.7 – 2.2 μM). Also inhibits NADH oxidation by cardiac sarcoplasmic reticulum (IC 50 = 3.4 nM). May be used to induce Parkinsonism in animal models. Inhibits autophagy by blocking lysosomal degradation of autophagic vacuoles
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