Potent inhibitor of NFκB in T-lymphocytes with almost complete inhibition at 200 nM. Completely inhibits IL-4 and IFN-γ production and suppresses IL-2 and TNF-α production at 50 nM in T-cells, without inhibiting AP-1 and NF-κB. Immunosuppresive activity is due to inhibition of cytokine gene...
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Potent inhibitor of NFκB in T-lymphocytes with almost complete inhibition at 200 nM. Completely inhibits IL-4 and IFN-γ production and suppresses IL-2 and TNF-α production at 50 nM in T-cells, without inhibiting AP-1 and NF-κB. Immunosuppresive activity is due to inhibition of cytokine gene expression via blocking NF-AT activity. Has anti-cancer properties via various pathways including ERK inhibition, ATM/ATR-Chk1/Chk2 activation, and p38 and JNK activation
This product is manufactured by TriBio Science and sold through ABMIUM without relabelling.
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TNF encodes a multifunctional pro-inflammatory cytokine in the tumour necrosis factor superfamily. This target hub connects accepted names and identifiers with ABMIUM antibodies, ELISA kits and related assay products.
Biological function: TNF is produced as a membrane-associated cytokine and can be released in soluble form. Signalling through TNFRSF1A (TNFR1) and TNFRSF1B (TNFR2) contributes to regulation of inflammation, immune responses, cell survival, differentiation and cell death.
