RI-1 is a potent and selective inhibitor of RAD51 (IC50 = 5-30 μM), a highly conserved protein that catalyzes DNA repair via homologous recombination. It specifically reduces gene conversion in human cells and stimulates single strand annealing. It covalently binds to Cys319 on the surface of...
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RI-1 is a potent and selective inhibitor of RAD51 (IC50 = 5-30 μM), a highly conserved protein that catalyzes DNA repair via homologous recombination. It specifically reduces gene conversion in human cells and stimulates single strand annealing. It covalently binds to Cys319 on the surface of RAD51 and disrupts protein-protein interaction. It potentiates the effect of DNA-damaging agents on tumor cells and is a novel tool for studying DNA repair in cells. Potentiates the killing of glioblastoma cells by ionizing radiation and alkylating drugs
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RAD51 identifies RAD51 recombinase in Homo sapiens (Human). This target record connects NCBI Gene 5888, UniProtKB Q06609 and related ABMIUM catalogue products.
