RECTAS a pre-mRNA splice modulator (Rectifier of Aberrant Splicing) was discovered in a small molecule screen for compounds that rectify aberrant IKBKAP splicing in cells from patients with familial dysautonomia. RECTAS (2 µM) increased the expression of IKAP and restored tRNA modifications. It...
Know who made it. See the evidence. Buy through one marketplace.
RECTAS a pre-mRNA splice modulator (Rectifier of Aberrant Splicing) was discovered in a small molecule screen for compounds that rectify aberrant IKBKAP splicing in cells from patients with familial dysautonomia. RECTAS (2 µM) increased the expression of IKAP and restored tRNA modifications. It directly interacts with CDC-like kinases enhancing SRSF6 phosphorylation. A combination treatment with RECTAS and phenylbutyric acid was shown to restore DJ-1 protein and mitochondrial dysfunction in Parkinson’s disease models
This product is manufactured by TriBio Science and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
