Inhibitor of BMI-1 (IC50 = 500 nM), part of the polycomb repressive complex 1 (PCR1). It inhibited endogenous BMI-1 expression in human colorectal HCT116 and human fibrosarcoma HT1080 tumor cells resulting in reduced tumor volume as well as reduced cancer initiating cell (CIC) number. PTC-209...
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Inhibitor of BMI-1 (IC50 = 500 nM), part of the polycomb repressive complex 1 (PCR1). It inhibited endogenous BMI-1 expression in human colorectal HCT116 and human fibrosarcoma HT1080 tumor cells resulting in reduced tumor volume as well as reduced cancer initiating cell (CIC) number. PTC-209 displayed potent in vivo antitumor effects in several cancer models including breast, head and neck, glioblastoma, prostate, colon, and rhabdomyosarcoma. It also promoted chemically-induced direct cardiac reprogramming of cardiac fibroblasts into cardiac myocytes
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