Potent and selective inhibitor of insulin-like growth factor 1 receptor (IGF1R) which is non-competitive with ATP. Displays no activity at IR, EGFR, FGFR or PDGFR. Inhibits IGF1R autophosphorylation IC50 ~ 1 nM. Displays antiproliferative activity in numerous tumor cell lines, IC50 = 0.05 – 15...
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Potent and selective inhibitor of insulin-like growth factor 1 receptor (IGF1R) which is non-competitive with ATP. Displays no activity at IR, EGFR, FGFR or PDGFR. Inhibits IGF1R autophosphorylation IC50 ~ 1 nM. Displays antiproliferative activity in numerous tumor cell lines, IC50 = 0.05 – 15 μM. Exhibits antiangiogenic activitiy. Attenuates intimal hyperplasia after vascular injury. Active in vivo
This product is manufactured by TriBio Science and sold through ABMIUM without relabelling.
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IGF1R identifies insulin like growth factor 1 receptor in Homo sapiens (Human). This target record connects NCBI Gene 3480, UniProtKB P08069 and related ABMIUM catalogue products.
