PF-4136309 (1341224-83-6) is a potent (hIC50 = 5.2 nM, mIC50 = 13 nM, rIC50 = 17 nM) and selective inhibitor of CCR2. PF-4136309 significantly decreased inflammatory monocytes in a mouse model of pancreatic cancer. In combination therapy with the FOLFIRINOX regimen, PF-4136309 reversed immune...
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PF-4136309 (1341224-83-6) is a potent (hIC50 = 5.2 nM, mIC50 = 13 nM, rIC50 = 17 nM) and selective inhibitor of CCR2. PF-4136309 significantly decreased inflammatory monocytes in a mouse model of pancreatic cancer. In combination therapy with the FOLFIRINOX regimen, PF-4136309 reversed immune suppression in the tumor microenvironment causing an influx of tumor infiltrating lymphocytes leading to overall enhanced efficacy in a phase 1b study
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CCR2 identifies C-C motif chemokine receptor 2 in Homo sapiens (Human). This target record connects NCBI Gene 729230, UniProtKB P41597 and related ABMIUM catalogue products.
