Manufactured by:TriBio Science
RUO

ODQ, Soluble guanylyl cyclase inhibitor

A potent and selective inhibitor of soluble guanylyl cyclase (sGC), IC50 = 20 nM). ODQ acts via competition with NO for the heme site of sGC where it binds irreversibly. ODQ does not inhibit NO-mediated macrophage toxicity, an activity that is unrelated to cGMP nor does it inhibit particulate...

SKU:
ABM147470-1
Manufacturer SKU
TBI1211-25MG | TBI1211-5MG
Product type
Biochemical Inhibitors
TargetSoluble guanylyl cyclase
Purity>98%

Manufacturer provenance

Manufactured by:
TriBio Science
Sold by:
ABMIUM
Fulfilled from:
Manufacturer facility or confirmed fulfilment location

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Product description

A potent and selective inhibitor of soluble guanylyl cyclase (sGC), IC50 = 20 nM). ODQ acts via competition with NO for the heme site of sGC where it binds irreversibly. ODQ does not inhibit NO-mediated macrophage toxicity, an activity that is unrelated to cGMP nor does it inhibit particulate GC. ODQ is an extremely useful tool to explore the involvement of the NO-cGMP pathway in cellular signaling and physiologic processes

Key facts & specifications
Also known as
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one
Molecular weight
187.15
Form / buffer
powder
Activity
A potent and selective inhibitor of soluble guanylyl cyclase (sGC), IC50 = 20 nM). ODQ acts via competition with NO for the heme site of sGC where it binds irreversibly. ODQ does not inhibit NO-mediated macrophage toxicity, an activity that is unrelated to cGMP nor does it inhibit particulate GC. ODQ is an extremely useful tool to explore the involvement of the NO-cGMP pathway in cellular signaling and physiologic processes.
Molecular formula
C 9 H 5 N 3 O 2
Solubility
Soluble in DMSO (up to 40 mg/ml)
Technical note
Stability: ≥ 2 years.
Identifiers & database references
Manufacturer SKU
TBI1211-25MG | TBI1211-5MG
CAS number
41443-28-1
Storage, stability & shipping
Storage conditions
-20°C
Shipped at
4°C
Long-term storage
-20°C
Compliance & documents
Datasheet
Open datasheet
Safety data sheet
Open SDS
Frequently asked questions
Who manufactured this product?

This product is manufactured by TriBio Science and sold through ABMIUM without relabelling.

Can ABMIUM ship this product internationally?

ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.

Can I check suitability before ordering?

Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.

Is this product for clinical use?

Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.

TriBio Science
£137.00