A potent and selective inhibitor of soluble guanylyl cyclase (sGC), IC50 = 20 nM). ODQ acts via competition with NO for the heme site of sGC where it binds irreversibly. ODQ does not inhibit NO-mediated macrophage toxicity, an activity that is unrelated to cGMP nor does it inhibit particulate...
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A potent and selective inhibitor of soluble guanylyl cyclase (sGC), IC50 = 20 nM). ODQ acts via competition with NO for the heme site of sGC where it binds irreversibly. ODQ does not inhibit NO-mediated macrophage toxicity, an activity that is unrelated to cGMP nor does it inhibit particulate GC. ODQ is an extremely useful tool to explore the involvement of the NO-cGMP pathway in cellular signaling and physiologic processes
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