A novel Bcl-2 homology domain-3 (BH3) mimetic. Inhibits primary acute myeloid leukemia (AML) progenitor cell proliferation (IC50=0.18 μM) and induces apoptosis in primary AML cells (IC50= 3.6 μM). Synergizes with other agents such as chloroquine and cytarabine in cytotoxicity against a variety...
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A novel Bcl-2 homology domain-3 (BH3) mimetic. Inhibits primary acute myeloid leukemia (AML) progenitor cell proliferation (IC50=0.18 μM) and induces apoptosis in primary AML cells (IC50= 3.6 μM). Synergizes with other agents such as chloroquine and cytarabine in cytotoxicity against a variety of cancer cells
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