NVP-213 is a reversible inhibitor of ceramide kinase (IC50 = 12 nM). At 10 nM, it inhibited ceramide-1-phosphate formation by >50% and at 100 nM it completely inhibited its formation in cell culture. NVP-231 was inactive against hSphK1/2, hPI3Ka, hPI4Kb, hVps34, hGCS, hSMS-1, CERT, and 500-fold...
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NVP-213 is a reversible inhibitor of ceramide kinase (IC50 = 12 nM). At 10 nM, it inhibited ceramide-1-phosphate formation by >50% and at 100 nM it completely inhibited its formation in cell culture. NVP-231 was inactive against hSphK1/2, hPI3Ka, hPI4Kb, hVps34, hGCS, hSMS-1, CERT, and 500-fold less potent against hDAGKa. NVP-231 inhibited breast and lung cancer cell proliferation via M phase arrest. It potently blocked cell migration and invasion in PANC-1 pancreatic cancer cells as well as MDA-MB-231 breast cancer cells
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