Potent (IC50 = 2.1 nM ADP-Glo assay; 4.8 nM Oxaloacetate coupled enzyme assay) allosteric inhibitor of ATP-citrate lyase. NDI-091143 suppressed growth and clonogenic ability in thyroid cancer cell lines FTC-133 and 8505C. It also synergistically potentiated the cytotoxicity of sorafenib
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Potent (IC50 = 2.1 nM ADP-Glo assay; 4.8 nM Oxaloacetate coupled enzyme assay) allosteric inhibitor of ATP-citrate lyase. NDI-091143 suppressed growth and clonogenic ability in thyroid cancer cell lines FTC-133 and 8505C. It also synergistically potentiated the cytotoxicity of sorafenib
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