Potent and selective p97 AAA ATPase inhibitor, IC50=100 nM. Inhibits degradation of a p97-dependent but not p97-independent proteasome substrate in a dual-reporter cell line. It impairs the endoplasmic reticulum-associated degradation (ERAD) pathway. ML241 and related inhibitors (DBeQ for...
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Potent and selective p97 AAA ATPase inhibitor, IC50=100 nM. Inhibits degradation of a p97-dependent but not p97-independent proteasome substrate in a dual-reporter cell line. It impairs the endoplasmic reticulum-associated degradation (ERAD) pathway. ML241 and related inhibitors (DBeQ for example) have differential responses to p97 mutants as well as the presence of cofactors suggesting the possibility of context-dependent p97 inhibitors
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