Selective blocker of TRPC4 channels (IC50 = 0.96 – 2.6 μM, depending on assay). Displays 19-fold selectivity against TRPC6 and 9-fold selectivity against TRPC5. Has no significant activity at TRPV1, TRPV3, TRPA1 and TRPM8 channels at concentrations up to 22 μM. A useful tool for exploring the...
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Selective blocker of TRPC4 channels (IC50 = 0.96 – 2.6 μM, depending on assay). Displays 19-fold selectivity against TRPC6 and 9-fold selectivity against TRPC5. Has no significant activity at TRPV1, TRPV3, TRPA1 and TRPM8 channels at concentrations up to 22 μM. A useful tool for exploring the involvement of TRPC and TRPC-like channels in cellular signaling and physiology
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