Mitoguazone is a potent and reversible inhibitor of S-adenosylmethionine decarboxylase (SAMD or AdoMetDC). SAMD is a component of the polyamine-biosynthetic pathway, thus inhibition may lead to changes in polyamine metabolism. Mitoguazone has also been shown to inhibit diamine oxidase and induce...
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Mitoguazone is a potent and reversible inhibitor of S-adenosylmethionine decarboxylase (SAMD or AdoMetDC). SAMD is a component of the polyamine-biosynthetic pathway, thus inhibition may lead to changes in polyamine metabolism. Mitoguazone has also been shown to inhibit diamine oxidase and induce spermidine/spermine N-acetyltransferase. Mitoguazone has been looked at as a potential anti-cancer treatment because of it’s ability to inhibit polyamine synthesis
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