Activates mitochondrial unfolded protein response (UPR MT ) and increases C. elegans lifespan. Clinically useful diuretic that inhibits the thiazide-sensitive Na + -Cl – cotransporter (NCC) (IC50 = 0.3 µM rat), blocking sodium reabsorption. Metolazone also inhibits human carbonic anhydrase...
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Activates mitochondrial unfolded protein response (UPR MT ) and increases C. elegans lifespan. Clinically useful diuretic that inhibits the thiazide-sensitive Na + -Cl – cotransporter (NCC) (IC50 = 0.3 µM rat), blocking sodium reabsorption. Metolazone also inhibits human carbonic anhydrase isoforms VII, XII, and XIII with nanomolar potency
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