A potent inhibitor of VEGFR2 and R3, IC50s=4.0 and 5.2 nM respectively. Also inhibits VEGFR1, FGFR1, PDGFR3b and Kit, IC50s=22, 46, 39 and 100 nM respectively. Suppresses lymph node and lung metastasis in human mammary breast tumor model. Suppresses tumor cell migration and invasion. Inhibits...
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A potent inhibitor of VEGFR2 and R3, IC50s=4.0 and 5.2 nM respectively. Also inhibits VEGFR1, FGFR1, PDGFR3b and Kit, IC50s=22, 46, 39 and 100 nM respectively. Suppresses lymph node and lung metastasis in human mammary breast tumor model. Suppresses tumor cell migration and invasion. Inhibits angiogenesis
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