Potent and selective PPARδ (NR1C2) agonist, EC50=1.2 nM and 1000-fold selective over other PPAR subtypes. Induces apolipoprotein A1-mediated cholesterol efflux in vitro.1 Improves hematopoietic stem cell maintenance. Prevents downregulation of AMPK caused by a high-fat diet in liver and...
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Potent and selective PPARδ (NR1C2) agonist, EC50=1.2 nM and 1000-fold selective over other PPAR subtypes. Induces apolipoprotein A1-mediated cholesterol efflux in vitro.1 Improves hematopoietic stem cell maintenance. Prevents downregulation of AMPK caused by a high-fat diet in liver and increases fatty acid oxidation. Upregulates human Sirt1 via Sp1 activation. Along with exercise, GW-501516 synergistically increases running endurance
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PPARD identifies peroxisome proliferator activated receptor delta in Homo sapiens (Human). This target record connects NCBI Gene 5467, UniProtKB Q03181 and related ABMIUM catalogue products.
