Selective and irreversible antagonist of peroxisome proliferator-activated receptor beta/delta (PPARβ/δ) (plC50 = 6.6), but not PPARα or ɣ. It covalently binds to Cys 249 in the PPARβ/δ binding site1. When applied topically, GSK-3787 showed efficacy against an inflammatory skin disease...
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Selective and irreversible antagonist of peroxisome proliferator-activated receptor beta/delta (PPARβ/δ) (plC50 = 6.6), but not PPARα or ɣ. It covalently binds to Cys 249 in the PPARβ/δ binding site1. When applied topically, GSK-3787 showed efficacy against an inflammatory skin disease resembling psoriasis in mice. Suppresses colorectal cancer tumorigenesis in Apc(δ580) mice
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PPARD identifies peroxisome proliferator activated receptor delta in Homo sapiens (Human). This target record connects NCBI Gene 5467, UniProtKB Q03181 and related ABMIUM catalogue products.
