β-Glucuronidases is a kind of lysosomal enzyme which belongs to the glycosidase family. It plays a critical role during the process of metabolic and detoxification, especially for the breakdown of complex carbohydrates in the human body. β -Glucuronidase level imbalance is related to many...
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β-Glucuronidases is a kind of lysosomal enzyme which belongs to the glycosidase family. It plays a critical role during the process of metabolic and detoxification, especially for the breakdown of complex carbohydrates in the human body. β -Glucuronidase level imbalance is related to many diseases, such as cancer, diabetes, liver and detoxification disorders, inflammation, autoimmune, and neuron degenerative diseases. Therefore, it is important to detect activity of β-Glucuronidase in samples to elucidate the pathology of diseases
Tribioscience’s β-Glucuronidase Activity Colorimetric Assay provides a simple and sensitive method for monitoring glucuronidase activity in biological samples (tissue, cells, serum, urine). This assay uses a synthetic p- nitrophenol derivative (R- p NP) as its substrate. The substrate releases a chromophore p NP under β-Glucuronidase, which can be measured at absorbance (OD 405 nm). The assay can detect as low as 50 µU of glucuronidase activity in a variety of samples. The reaction was shown in Fig. 1 as below
Determination of β-Glucuronidases activity in biological samples
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Sample compatibility evidence using the same validation key.
| Sample type | Sample compatibility |
|---|---|
| Serum | |
| Urine |
This product is manufactured by TriBio Science and sold through ABMIUM without relabelling.
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