Novel inducer of ferroptosis acting via degradation of GPX4 and activation of squalene synthase (leading to CoQ10 depletion, a compound which inhibits ferroptosis via an unknown mechanism). FIN56 inhibited glioblastoma growth in vitro and in vivo via induction of ferroptosis as well as lysosomal...
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Novel inducer of ferroptosis acting via degradation of GPX4 and activation of squalene synthase (leading to CoQ10 depletion, a compound which inhibits ferroptosis via an unknown mechanism). FIN56 inhibited glioblastoma growth in vitro and in vivo via induction of ferroptosis as well as lysosomal membrane permeabilization
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