Etomoxir (828934-41-4) is an irreversible inhibitor of mitochondrial carnitine palmitoyl transferase 1 (CPT1). It is widely used to study fatty acid oxidation. Etomoxir has been investigated as a therapeutic agent for heart disease, diabetes, and cancer. Use of etomoxir in concentrations greater...
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Etomoxir (828934-41-4) is an irreversible inhibitor of mitochondrial carnitine palmitoyl transferase 1 (CPT1). It is widely used to study fatty acid oxidation. Etomoxir has been investigated as a therapeutic agent for heart disease, diabetes, and cancer. Use of etomoxir in concentrations greater than 5 µM induces acute production of ROS with associated evidence of severe oxidative stress in proliferating T cells indicating a loss of specificity for CTP1 at these concentrations. 200 µM etomoxir inhibited complex I of the electron transport chain
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