Angiogenesis inhibitor that suppresses expression of integrins α2, α3, α5, and ß1. Broad-spectrum antitumor and antiangiogenic effects are mainly mediated via integrin α2 suppression. E7820 has been identified as a molecular glue that induces proteasomal degradation of the U2AF-related splicing...
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Angiogenesis inhibitor that suppresses expression of integrins α2, α3, α5, and ß1. Broad-spectrum antitumor and antiangiogenic effects are mainly mediated via integrin α2 suppression. E7820 has been identified as a molecular glue that induces proteasomal degradation of the U2AF-related splicing factor CAPERα (RBM39) via CRL4 DCAF15 mediated ubiquitination in human cancer cell lines. E7820 has also been shown to induce degradation of the aryl hydrocarbon receptor nuclear translator (ARNT), a protein essential in maintaining cellular homeostasis in response to environmental stress
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