A specific competitive inhibitor of nucleotide binding to Rab7, an endosome-localized small GTPase. It interferes with the Rab7-RILP interaction, locking the GTPase in an inactive conformation. Impairs B cell class switching and plasma cell survival dampening, the pathogenic autoantibody...
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A specific competitive inhibitor of nucleotide binding to Rab7, an endosome-localized small GTPase. It interferes with the Rab7-RILP interaction, locking the GTPase in an inactive conformation. Impairs B cell class switching and plasma cell survival dampening, the pathogenic autoantibody response in lupus. Inhibits the Arf-like small GTPase Arl8b, blocking cellular egress of β-coronaviruses (SARS-CoV-2) which utilize a lysosomal exocytosis pathway
This product is manufactured by TriBio Science and sold through ABMIUM without relabelling.
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