Mitochondrial oxidative phosphorylation inhibitor A mitochondrial protonophore uncoupler with fewer off-target effects (EC50 = 270 nM in L6 myoblast mitochondria). Compared to FCCP, an uncoupler of equal potency, BAM15 stimulates a higher maximum rate of mitochondrial respiration and does not...
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Mitochondrial oxidative phosphorylation inhibitor
A mitochondrial protonophore uncoupler with fewer off-target effects (EC50 = 270 nM in L6 myoblast mitochondria). Compared to FCCP, an uncoupler of equal potency, BAM15 stimulates a higher maximum rate of mitochondrial respiration and does not depolarize the plasma membrane. Stimulates energy expenditure, protects against obesity and improves glycemic control in rodent models. Reverses diet-induced obesity and insulin resistance in mice. Attenuates transportation-induced apoptosis in iPS-differentiated retinal tissue
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