Anacardic acids occur in cashew nut shells and are similar in structure to urushiols, the irritating components of poison ivy. Anacardic acid inhibits histone acetyltransferases (HATs) p300 (IC50 = 8.5 µM) and PCAF (IC50 = 5.0 µM) with no effect on HDACs. It also suppresses expression or...
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Anacardic acids occur in cashew nut shells and are similar in structure to urushiols, the irritating components of poison ivy. Anacardic acid inhibits histone acetyltransferases (HATs) p300 (IC50 = 8.5 µM) and PCAF (IC50 = 5.0 µM) with no effect on HDACs. It also suppresses expression or activity of proteins involved in invasion and angiogenesis, e.g. MMP-2 (IC50 = 11 µM) and -92. 6-PDSA, a saturated form of anacardic acid, induces macrophage activation via MAPK and NF-κB3. When used at 125 µM, it sensitized cancer cells to radiation therapy by reducing histone expression. It also blocks inducible and constitutive activation of NF-κB in leukemia cells
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