CA IV polyclonal antibody; host Rabbit; reactivity Human, Rat, Mouse
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carbonic anhydrase 4(CA4) Homo sapiens Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. This gene encodes a glycosylphosphatidyl-inositol-anchored membrane isozyme expressed on the luminal surfaces of pulmonary (and certain other) capillaries and proximal renal tubules. Its exact function is not known; however, it may have a role in inherited renal abnormalities of bicarbonate transport. [provided by RefSeq, Jul 2008],
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Species / reactivity | WB | ELISA |
|---|---|---|
| Human,Rat,Mouse |
This product is manufactured by Reed Biotech and sold through ABMIUM without relabelling.
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Carbonic anhydrase 4 (CA4; carbonic anhydrase IV/CA-IV) is a GPI-anchored membrane zinc metalloenzyme with an extracellular catalytic domain. It catalyses reversible CO2 hydration and is studied in extracellular pH regulation, bicarbonate transport, renal physiology and retinal acid handling.
Biological function: CA4 catalyses reversible conversion of carbon dioxide and water to bicarbonate and protons at the cell surface, helping couple extracellular carbon chemistry to pH homeostasis. Reviewed UniProt also supports roles in bicarbonate-transporter activity and retinal acid removal.
