ATP-citrate synthase polyclonal antibody; host Rabbit; reactivity Human, Mouse, Rat, Monkey
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ATP citrate lyase(ACLY) Homo sapiens ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Dec 2014],
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Species / reactivity | WB | IF/ICC | ELISA |
|---|---|---|---|
| Human,Mouse,Rat,Monkey |
This product is manufactured by Reed Biotech and sold through ABMIUM without relabelling.
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ACLY is ATP citrate lyase, also called ATP-citrate synthase. This record links the verified human identity (NCBI Gene 47; UniProt P53396) to ABMIUM catalogue products.
Biological function: ATP citrate lyase (ACLY) generates cytosolic acetyl-CoA by converting citrate and coenzyme A in an ATP-dependent reaction that also produces oxaloacetate. The acetyl-CoA supplied by ACLY supports pathways including fatty-acid and cholesterol biosynthesis.
