ADA15 polyclonal antibody; host Rabbit; reactivity Human, Rat, Mouse
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ADAM metallopeptidase domain 15(ADAM15) Homo sapiens The protein encoded by this gene is a member of the ADAM (a disintegrin and metalloproteinase) protein family. ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. This protein contains multiple functional domains including a zinc-binding metalloprotease domain, a disintegrin-like domain, as well as a EGF-like domain. Through its disintegrin-like domain, this protein specifically interacts with the integrin beta chain, beta 3. It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein may function in cell-cell adhesion as well as in cellular signaling. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008],
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Species / reactivity | WB | ELISA |
|---|---|---|
| Human,Rat,Mouse |
This product is manufactured by Reed Biotech and sold through ABMIUM without relabelling.
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ADAM metallopeptidase domain 15 (ADAM15), also known as MDC15 or metargidin, is a membrane-associated disintegrin metalloprotease. This ABMIUM target guide links the verified human target identity to catalogue-backed research products and authoritative NCBI/UniProt evidence.
Biological function: ADAM metallopeptidase domain 15 (ADAM15/MDC15) is a membrane-associated disintegrin metalloprotease. Reviewed UniProt describes gelatinolytic and collagenolytic activity together with roles in cell adhesion and migration, E-cadherin cleavage, wound-healing processes and neovascularization-related biology.
