Puma antibody from Promab.
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BBC3 isoform 3 Does not affect cell growth.
For research use only.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Species | WB | IHC | IHC-P | IHC-F | IF/ICC | Flow Cytometry | ELISA | IP | ChIP |
|---|---|---|---|---|---|---|---|---|---|
| Human |
This product is manufactured by Promab and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
BBC3 (BCL2 binding component 3), widely known as PUMA or p53 up-regulated modulator of apoptosis, is a pro-apoptotic BCL-2 family target studied in mitochondrial cell-death signalling. This catalogue-backed record links verified human BBC3 identity with Abmium research reagents.
Biological function: BBC3/PUMA belongs to the BH3-only pro-apoptotic arm of the BCL-2 family. Pro-apoptotic BBC3 isoforms can engage anti-apoptotic BCL-2 family proteins and promote mitochondrial outer-membrane permeabilization, cytochrome c release and downstream caspase activation. Alternative splicing produces multiple isoforms, so isoform context should be considered when interpreting experimental data.
