ABMIUM
Manufactured by:Promab
RUO

Anti-FBXL2 Rabbit Polyclonal Antibody

FBXL2 antibody from Promab.

SKU:
ABM417393-1
Product type
Primary antibodies
TargetFBXL2
ApplicationsWB, IHC-P, Flow Cytometry
Species / reactivityHuman, Mouse, Rat

Manufacturer provenance

Manufactured by:
Promab
Sold by:
ABMIUM
Fulfilled from:
Manufacturer facility or confirmed fulfilment location

Know who made it. See the evidence. Buy through one marketplace.

Product description

Calcium-activated substrate recognition component of the SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex, SCF(FBXL2), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 does not seem to target phosphodegron within its substrates but rather calmodulin-binding motifs and is thereby antagonized by calmodulin. This is the case for the cyclins CCND2 and CCND3 which polyubiquitination and subsequent degradation are inhibited by calmodulin.

For research use only.

Key facts & specifications
Also known as
F-box/LRR-repeat protein 2; F-box and leucine-rich repeat protein 2 {ECO:0000312; HGNC:HGNC:13598}; F-box protein FBL2/FBL3 {ECO:0000303; PubMed:10945468; ECO:0000312; EMBL:AAF045101}; FBXL2 (HGNC:13598); FBXL2; F-box and leucine rich repeat protein 2
Host species
Rabbit
Clonality
Polyclonal
Conjugation
Unconjugated
Immunogen
This FBXL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 366-395 amino acids from the C-terminal region of human FBXL2.
Molecular weight
47.1 kDa
Validation & performance evidence
ABMIUM Validated™ ABMIUM Verified™ Expected performance Not suitable

Application matrix

Evidence status by application and model.

SpeciesWBIHCIHC-PIHC-FIF/ICCFlow CytometryELISAIPChIP
Human
Mouse
Rat
Identifiers & database references
Gene symbol
FBXL2
Gene ID
25827
UniProt accession
Q9UKC9
Ensembl
ENSG00000153558
HGNC
13598
OMIM
605652
Storage, stability & shipping
Short-term storage
4°C (short term)
Long-term storage
-20°C (long term); aliquot and avoid repeated freeze-thaw cycles
Storage buffer
Purified antibody in PBS with 0.05% sodium azide.
Aliquoting guidance
Aliquot to avoid repeated freeze-thaw.
Compliance & documents
CE marked
No
Frequently asked questions
Who manufactured this product?

This product is manufactured by Promab and sold through ABMIUM without relabelling.

Can ABMIUM ship this product internationally?

ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.

Can I check suitability before ordering?

Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.

Is this product for clinical use?

Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.

Promab
£174.20