Recombinant Human KIF15 Protein, N-His

Introduction
Recombinant Human KIF15 Protein, also known as kinesin family member 15, is a motor protein that plays a crucial role in cell division and movement. This protein is encoded by the KIF15 gene and is highly conserved among different species. Recombinant Human KIF15 Protein is widely used in various research applications due to its unique structure and activity.

Structure of Recombinant Human KIF15 Protein
Recombinant Human KIF15 Protein is a member of the kinesin-12 family, which is a subfamily of kinesin motor proteins. It consists of a motor domain, a stalk domain, and a tail domain. The motor domain contains the ATP binding and hydrolysis site, which is responsible for the movement of the protein along microtubules. The stalk domain acts as a linker between the motor domain and the tail domain, which is involved in protein-protein interactions. The tail domain is responsible for cargo binding and determines the specific function of the protein.

Activity of Recombinant Human KIF15 Protein
Recombinant Human KIF15 Protein is a microtubule-based motor protein that is involved in various cellular processes, including mitosis, cytokinesis, and cell migration. It plays a crucial role in the assembly and maintenance of the mitotic spindle during cell division. During cytokinesis, it is responsible for the separation of the two daughter cells by moving along the microtubules and pulling the cell membrane towards the center of the cell. In addition, Recombinant Human KIF15 Protein is also involved in cell migration by interacting with actin filaments and regulating their dynamics.

Application of Recombinant Human KIF15 Protein
Recombinant Human KIF15 Protein has a wide range of applications in both basic research and drug discovery. One of its main applications is in studying the mechanisms of cell division and cell movement. By using recombinant KIF15 protein, researchers can investigate the role of this protein in various cellular processes and understand its interaction with other proteins. This can lead to a better understanding of diseases such as cancer, where abnormal cell division and migration play a crucial role.

In addition, Recombinant Human KIF15 Protein is also used in drug discovery and development. As this protein is involved in cell division and migration, it is a potential target for anti-cancer drugs. By studying the structure and activity of Recombinant Human KIF15 Protein, researchers can design inhibitors that can block its function and potentially inhibit tumor growth. Furthermore, this protein can also serve as a biomarker for cancer diagnosis and prognosis.

Recombinant Human KIF15 Protein is also used in the production of therapeutic antibodies. The tail domain of this protein can be fused with the Fc region of antibodies, resulting in a bispecific antibody that can target both microtubules and specific antigens. This approach has shown promising results in the treatment of various types of cancer, including breast cancer and leukemia.

Conclusion
In conclusion, Recombinant Human KIF15 Protein is a crucial motor protein that plays a significant role in cell division and movement. Its unique structure and activity make it an essential tool for studying various cellular processes and developing potential treatments for diseases such as cancer. With its wide range of applications, Recombinant Human KIF15 Protein continues to be a valuable resource for the scientific community.

ProteoGenix catalogue number ARO-P12427. For research use only.

Host: Escherichia coli (E.coli); Expression system: Prokaryotic expression; Molecular weight: 40.58 kDa; Fragment: Ala26-Gly375; Buffer: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol..

Available configurations: 50ug, 100ug, 1mg.

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