Anti-CD28 Biosimilar – Anti-CD28(Tp44) mAb – Research Grade

Introduction

Anti-CD28 Biosimilar – Anti-CD28(Tp44) mAb – Research Grade is a monoclonal antibody that targets the CD28 protein, a co-stimulatory molecule found on the surface of T cells. This biosimilar is a highly specific and potent therapeutic agent that has been extensively studied for its potential use in various immune-related disorders.

Structure

Anti-CD28(Tp44) mAb is a recombinant antibody that is produced using advanced biotechnology techniques. It is a fully humanized IgG1 antibody, meaning it is derived from human cells and has a structure similar to natural antibodies found in the body. This structure allows for high binding affinity and specificity to the CD28 protein.

The antibody consists of two heavy chains and two light chains, each with a variable region that recognizes the CD28 protein and a constant region that mediates effector functions. The variable regions are responsible for the specificity of the antibody, while the constant regions play a role in immune response activation and regulation.

Activity

The main function of Anti-CD28(Tp44) mAb is to block the interaction between CD28 and its ligands, CD80 and CD86, on antigen-presenting cells. This interaction is crucial for T cell activation and proliferation, and by inhibiting it, the antibody can modulate the immune response.

In addition to blocking CD28, Anti-CD28(Tp44) mAb also activates the cytotoxic T lymphocyte-associated protein 4 (CTLA-4) pathway, which further suppresses T cell activation. This dual mechanism of action makes the antibody a potent immunosuppressive agent.

Application

Anti-CD28(Tp44) mAb has shown promising results in preclinical studies and is currently being evaluated in clinical trials for various immune-related disorders. Some of the potential applications of this biosimilar include:

1. Organ transplantation: The antibody has shown to be effective in preventing organ rejection in animal models by suppressing T cell activation. Clinical trials are currently underway to evaluate its use in human organ transplant recipients.

2. Autoimmune diseases: The dysregulation of T cell activation is a key feature of autoimmune diseases. Anti-CD28(Tp44) mAb has the potential to modulate this process and has shown promising results in preclinical studies for diseases such as rheumatoid arthritis and multiple sclerosis.

3.

Cancer immunotherapy: T cells play a crucial role in the body’s immune response against cancer cells. By inhibiting T cell activation, Anti-CD28(Tp44) mAb can potentially enhance the anti-tumor immune response. Clinical trials are currently investigating its use in combination with other cancer treatments.

4. Allergic diseases: T cell-mediated inflammation is a hallmark of allergic diseases such as asthma and eczema. Anti-CD28(Tp44) mAb has shown to be effective in reducing inflammation and symptoms in preclinical studies and is being evaluated in clinical trials for these conditions.

Conclusion

Anti-CD28 Biosimilar – Anti-CD28(Tp44) mAb – Research Grade is a highly specific and potent therapeutic agent that targets the CD28 protein on T cells. Its dual mechanism of action of blocking CD28 and activating CTLA-4 makes it a promising treatment option for various immune-related disorders. Ongoing clinical trials will provide further insight into its efficacy and safety, and it has the potential to become a valuable addition to the current treatment options for these diseases.

ProteoGenix catalogue number PX-TA1625. For research use only.

Target: CD28 Biosimilar – Anti-CD28(Tp44) mAb – Research Grade; Clonality: Monoclonal Antibody; Expression system: Mammalian cells; Purity: >85%; Buffer: PBS buffer pH7.5; Applications: ELISA, WB.

Available configurations: 50ug, 100ug, 1mg.

Download the manufacturer datasheet