ELISA-Kit geliefert von Boster Bio
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Die Gewebeinhibitoren von Metalloproteinasen (TIMPs) sind natürliche Inhibitoren der Matrix-Metalloproteinasen, einer Gruppe von Zink-bindenden Endopeptidasen, die am Abbau der extrazellulären Matrix beteiligt sind. Das TIMP3-Gen wird in vielen Geweben exprimiert, mit der höchsten Expression in der Plazenta. TIMP3 kodiert einen potenten Angiogenese-Inhibitor und ist bei der Sorsby-Fundusdystrophie mutiert, einer makulären degenerativen Erkrankung mit submakulärer choroidaler Neovaskularisation. Das TIMP3-Gen ist auf 22q12.1-q13.2 kartiert. Mutationen im TIMP3-Gen verursachen die autosomal-dominante Erkrankung Sorsby-Fundusdystrophie (SFD).
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Sample compatibility evidence using the same validation key.
| Sample type | Probenkompatibilität | Assay-Bereich | Sensitivität | Spezifität |
|---|---|---|---|---|
| Zellkulturüberstände | ||||
| Serum | ||||
| Plasma (Heparin | ||||
| EDTA) und Speichel. |
This product is manufactured by Boster Bio and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
TIMP3 identifies TIMP metallopeptidase inhibitor 3 in Homo sapiens (Human). This target record connects NCBI Gene 7078, UniProtKB P35625 and related ABMIUM catalogue products.
