ELISA-Kit geliefert von Boster Bio
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TFPI (Tissue factor pathway inhibitor), auch bekannt als EPI, LACI oder TFPI1, ist ein einzelkettiges Polypeptid, das den Faktor Xa (Xa) und Thrombin (Faktor IIa) reversibel hemmen kann. Das Gen für TFPI befindet sich auf Chromosom 2q31-q32.1 und hat neun Exons, die sich über 70 kb erstrecken. TFPI besteht aus einem stark negativ geladenen Amino-Terminus, drei tandemartig verknüpften Kunitz-Domänen und einem stark positiv geladenen Carboxy-Terminus. TFPI trägt signifikant zur Hemmung von Xa in vivo bei, obwohl es nur in Konzentrationen von 2,5 nM vorhanden ist.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Sample compatibility evidence using the same validation key.
| Sample type | Probenkompatibilität | Assay-Bereich | Sensitivität | Spezifität |
|---|---|---|---|---|
| Zellkulturüberstände | ||||
| Zelllysate | ||||
| Serum und Plasma (Heparin | ||||
| EDTA). |
This product is manufactured by Boster Bio and sold through ABMIUM without relabelling.
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Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
TFPI identifies tissue factor pathway inhibitor in Homo sapiens (Human). This target record connects NCBI Gene 7035, UniProtKB P10646 and related ABMIUM catalogue products.
Biological function: Tissue factor pathway inhibitor (TFPI; LACI/EPI) is a secreted Kunitz-type serine protease inhibitor that restrains initiation of the extrinsic coagulation pathway by inhibiting factor Xa and the tissue factor-factor VIIa complex.
