ELISA-Kit geliefert von Boster Bio
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RAGE, der Rezeptor für Advanced Glycation Endproducts, ist ein 35 kD großes Transmembranrezeptor der Immunglobulin-Superfamilie. Er ist auch bekannt als „AGER“. Das AGER-Gen ist durch Kartierung mittels kontiguierender Cosmide und YAC-Klone sowie durch Fluoreszenz-in-situ-Hybridisierung auf Chromosom 6p21.3 kartiert. Die Expression von RAGE ist besonders erhöht in Neuronen in der Nähe von Ablagerungen von Amyloid-Beta-Peptid und neurofibrillären Tangles. RAGE wurde mit mehreren chronischen Krankheiten in Verbindung gebracht, die vermutlich auf Gefäßschäden zurückzuführen sind. Es wird angenommen, dass die Pathogenese die Ligandenbindung umfasst, woraufhin RAGE die Aktivierung des Nukleären Faktors Kappa B (NF-kappaB) signalisiert.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Sample compatibility evidence using the same validation key.
| Sample type | Probenkompatibilität | Assay-Bereich | Sensitivität | Spezifität |
|---|---|---|---|---|
| Zellkulturüberstände | ||||
| Zelllysate | ||||
| Serum und Plasma (Heparin | ||||
| EDTA). |
This product is manufactured by Boster Bio and sold through ABMIUM without relabelling.
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Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
AGER is the advanced glycosylation end-product specific receptor, commonly known as RAGE. It is a multiligand cell-surface receptor that senses advanced glycation end products and other endogenous stress-associated ligands, linking extracellular stress signals to inflammatory cellular responses.
Biological function: AGER/RAGE is an immunoglobulin-superfamily pattern-recognition receptor that binds multiple structurally diverse ligands, including advanced glycation end products, S100 proteins and HMGB1. Ligand engagement activates intracellular signalling programmes that can include NF-kappa-B and other inflammatory pathways, allowing cells to respond to tissue stress and damage-associated signals.
