ELISA-Kit geliefert von Boster Bio
Know who made it. See the evidence. Buy through one marketplace.
CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4), auch bekannt als CD152 (Cluster of differentiation 152), ist ein Proteinrezeptor, der das Immunsystem herunterreguliert. CTLA4 ist ein Mitglied der Immunglobulin-Superfamilie, das auf der Oberfläche von Helfer-T-Zellen exprimiert wird und ein hemmendes Signal an T-Zellen überträgt. CTLA4 ähnelt dem T-Zell-kostimulatorischen Protein CD28, und beide Moleküle binden an CD80 und CD86, auch B7-1 bzw. B7-2 genannt, auf antigenpräsentierenden Zellen. CTLA4 überträgt ein hemmendes Signal an T-Zellen, während CD28 ein stimulierendes Signal überträgt. Die Blockade der CTLA4-Expression in vitro verstärkte die HIV-spezifische Funktion CD4-positiver T-Zellen.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Sample compatibility evidence using the same validation key.
| Sample type | Probenkompatibilität | Assay-Bereich | Sensitivität | Spezifität |
|---|---|---|---|---|
| Zellkulturüberstände | ||||
| Serum und Plasma (Heparin) |
This product is manufactured by Boster Bio and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
CTLA4 identifies cytotoxic T-lymphocyte associated protein 4 in Homo sapiens (Human). This target record connects NCBI Gene 1493, UniProtKB P16410 and related ABMIUM catalogue products.
Biological function: CTLA4 (CD152) is an inhibitory immune receptor expressed by activated T cells and regulatory T cells. It binds the B7 ligands CD80 and CD86 and counterbalances costimulatory signalling, limiting T-cell activation.
