ELISA-Kit geliefert von Boster Bio
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Komplementfaktor H (CFH), ursprünglich bekannt als Beta-1H Globulin, ist ein Serumglykoprotein, das die Funktion des alternativen Komplementweges in der flüssigen Phase und auf Zelloberflächen reguliert. Es bindet an C3b, beschleunigt den Zerfall der Konvertase C3bBb des alternativen Weges und fungiert auch als Kofaktor für Komplementfaktor I, einen weiteren C3b-Inhibitor. Das CFH-Gen befindet sich auf Chromosom 1q32-q32.1 innerhalb eines Genclusters, der die regulatorischen Komplementkomponenten der C3-Aktivierung (RCA für "regulators of complement activation") kodiert. Dieser Gencluster umfasst den Decay-Accelerating Factor (DAF), C4-bindendes Protein (C4BPA und C4BPB) und die Faktor-H-verwandten Gene CFHR1, CFHR2, CFHR3, CFHR4 und CFHR5, unter anderem. Die Genfamilie ist durch mehrere Duplikationsereignisse entstanden.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Sample compatibility evidence using the same validation key.
| Sample type | Probenkompatibilität | Assay-Bereich | Sensitivität | Spezifität |
|---|---|---|---|---|
| Zellkulturüberstände | ||||
| Zelllysate | ||||
| Serum und Plasma (Heparin | ||||
| EDTA). |
This product is manufactured by Boster Bio and sold through ABMIUM without relabelling.
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Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
CFH identifies complement factor H in Homo sapiens (Human). This target record connects NCBI Gene 3075, UniProtKB P08603 and related ABMIUM catalogue products.
