ELISA-Kit geliefert von Boster Bio
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Apolipoprotein H (Apo-H), früher bekannt als β2-Glykoprotein I und Beta-2-Glykoprotein I, ist ein multifunktionales 38 kDa Apolipoprotein, das beim Menschen vom APOH-Gen kodiert wird. Dieses Gen ist auf 11 E1; 11 71.8 Cm kartiert. Apolipoprotein H wurde in eine Vielzahl von physiologischen Signalwegen involviert, einschließlich des Lipoproteinstoffwechsels, der Gerinnung und der Produktion von Antiphospholipid-Autoantikörpern. APOH könnte ein notwendiger Kofaktor für die anionische Phospholipidbindung durch die Antiphospholipid-Autoantikörper sein, die im Serum vieler Patienten mit Lupus und primärem Antiphospholipid-Syndrom gefunden werden, aber es scheint nicht für die Reaktivität von Antiphospholipid-Autoantikörpern erforderlich zu sein, die mit Infektionen assoziiert sind.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Sample compatibility evidence using the same validation key.
| Sample type | Probenkompatibilität | Assay-Bereich | Sensitivität | Spezifität |
|---|---|---|---|---|
| Zellkulturüberstände | ||||
| Serum und Plasma (Heparin | ||||
| EDTA). |
This product is manufactured by Boster Bio and sold through ABMIUM without relabelling.
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Apolipoprotein H (APOH), also known as beta-2-glycoprotein 1 (B2GPI), is a circulating plasma glycoprotein that associates with lipoproteins and anionic phospholipid surfaces. It is studied in lipoprotein metabolism, coagulation and antiphospholipid-antibody biology.
Biological function: APOH/beta-2-glycoprotein 1 is a plasma lipoprotein-associated glycoprotein with affinity for negatively charged phospholipid surfaces. NCBI describes roles and associations in lipoprotein metabolism, coagulation and hemostasis, and notes that beta-2-GPI can act as a cofactor for antiphospholipid autoantibody binding.
