ELISA-Kit geliefert von Boster Bio
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Das CD27-Antigen, auch CD27 oder TNFRSF7 genannt, ist ein Tumornekrosefaktor-Rezeptor. Dieses Gen ist auf 12p13.31 kartiert. Das von diesem Gen kodierte Protein gehört zur TNF-Rezeptor-Superfamilie. Dieser Rezeptor ist für die Generierung und langfristige Aufrechterhaltung der T-Zell-Immunität erforderlich. Er bindet an den Liganden CD70 und spielt eine Schlüsselrolle bei der Regulierung der B-Zell-Aktivierung und der Immunglobulinsynthese. Dieser Rezeptor überträgt Signale, die zur Aktivierung von NF-kappaB und MAPK8/JNK führen. Es wurde gezeigt, dass die Adaptorproteine TRAF2 und TRAF5 den Signalprozess dieses Rezeptors vermitteln. Das CD27-bindende Protein (SIVA), ein proapoptotisches Protein, kann an diesen Rezeptor binden und spielt vermutlich eine wichtige Rolle bei der durch diesen Rezeptor induzierten Apoptose.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Sample compatibility evidence using the same validation key.
| Sample type | Probenkompatibilität | Assay-Bereich | Sensitivität | Spezifität |
|---|---|---|---|---|
| Zellkulturüberstände und Serum |
This product is manufactured by Boster Bio and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
CD27 molecule (CD27), also known as TNFRSF7, is a TNF-receptor-superfamily costimulatory receptor involved in adaptive immune signalling. ABMIUM catalogue products linked below support research on CD27/TNFRSF7 biology.
Biological function: CD27 molecule (CD27/TNFRSF7) encodes a TNF-receptor-superfamily costimulatory receptor. Binding of its ligand CD70 supports antigen-specific T-cell activation and expansion and contributes to B-cell activation and immunoglobulin responses, with signalling through pathways including NF-kappaB and JNK.
