ELISA-Kit von Boster Bio
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Cluster of differentiation 97 ist ein Protein, das auch als BL-Ac [F2] bekannt ist und durch das ADGRE5-Gen kodiert wird. Das CD97-Gen wurde mittels Fluoreszenz-in-situ-Hybridisierung auf 19p13.2-p13.12 kartiert. Im Immunsystem ist CD97 als kritischer Mediator der Wirtsabwehr bekannt. Bei der Aktivierung von lymphoiden, myeloischen Zellen und Neutrophilen wird CD97 hochreguliert, um die Adhäsion und Migration zu Entzündungsstellen zu fördern. Darüber hinaus wurde gezeigt, dass CD97 die Granulozytenhomöostase reguliert. CD97 wird im sarkoplasmatischen Retikulum und am peripheren Sarkolemm in der Skelettmuskulatur exprimiert. Das Fehlen von CD97 beeinträchtigt jedoch nur die Struktur des sarkoplasmatischen Retikulums, nicht aber die Funktion der Skelettmuskulatur.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Sample compatibility evidence using the same validation key.
| Sample type | Probenkompatibilität | Assay-Bereich | Empfindlichkeit | Spezifität |
|---|---|---|---|---|
| Zellkulturüberstände | ||||
| Zelllysate | ||||
| Serum und Plasma (Heparin | ||||
| EDTA). |
This product is manufactured by Boster Bio and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
Adhesion G protein-coupled receptor E5 (ADGRE5), widely known as CD97, is an adhesion GPCR expressed prominently in immune-cell contexts. The human ADGRE5 target links NCBI Gene 976 and reviewed UniProtKB P48960 to ABMIUM catalogue reagents for research use.
Biological function: ADGRE5/CD97 is an EGF-TM7 family adhesion G protein-coupled receptor. The receptor undergoes autoproteolytic processing into a large extracellular subunit and a seven-transmembrane subunit that remain associated at the cell surface. Curated NCBI and UniProt records support roles in cell adhesion and signalling, particularly during leukocyte activation and migration; extracellular EGF-like repeats participate in binding partners including CD55 and chondroitin sulfate.
