ELISA-Kit geliefert von Boster Bio
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CD14, Cluster of differentiation 14, Einzelkopie-Gen, das 2 Proteinformen kodiert: ein 50- bis 55-kD Glycosylphosphatidylinositol-verankertes Membranprotein (mCD14) und ein von Monozyten oder der Leber stammendes lösliches Serumprotein (sCD14), dem der Anker fehlt. Durch In-situ-Hybridisierung und Untersuchung der somatischen Zellhybrid-DNA wurde gezeigt, dass das Gen an den Banden 5q23-q31 lokalisiert ist. CD14 fungiert als Korezeptor (zusammen mit dem Toll-like-Rezeptor TLR 4 und MD-2) für den Nachweis von bakteriellen Lipopolysacchariden (LPS). CD14 kann LPS nur in Anwesenheit des Lipopolysaccharid-bindenden Proteins (LBP) binden. Obwohl LPS als sein Hauptligand gilt, erkennt CD14 auch andere Pathogen-assoziierte molekulare Muster.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Sample compatibility evidence using the same validation key.
| Sample type | Probenkompatibilität | Assay-Bereich | Sensitivität | Spezifität |
|---|---|---|---|---|
| Zellkulturüberstände | ||||
| Serum und Plasma (Heparin | ||||
| EDTA | ||||
| Citrat). |
This product is manufactured by Boster Bio and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
CD14 identifies CD14 molecule in Homo sapiens (Human). This target record connects NCBI Gene 929, UniProtKB P08571 and related ABMIUM catalogue products.
Biological function: CD14 is a co-receptor for bacterial lipopolysaccharide. With LBP it transfers LPS to the LY96/TLR4 complex, supporting innate immune signalling and inflammatory cytokine responses.
