ELISA-Kit geliefert von Boster Bio
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Die Carboanhydrase III (CA3) ist ein Enzym, das beim Menschen vom CA3-Gen kodiert wird. CA3 gehört zu einer Multigenfamilie, die Carboanhydrase-Isoenzyme kodiert. Es ist an 8q21.2 kartiert. Das Gen erstreckt sich über 10,3 kb und enthält sieben Exons und sechs Introns. Mithilfe eines cDNA-Klons des CA3-Gens in der Studie von Mensch-Nager-Hybriden wurde das Gen auf Chromosom 8 kartiert, das einen Cluster von CA-Genen trägt. Die Expression des CA3-Gens ist streng gewebespezifisch und in hohen Mengen in der Skelettmuskulatur und in viel geringeren Mengen in der Herz- und glatten Muskulatur vorhanden. Ein Teil der Träger der Duchenne-Muskeldystrophie weist einen höheren CA3-Spiegel als normal auf.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Sample compatibility evidence using the same validation key.
| Sample type | Probenkompatibilität | Assay-Bereich | Sensitivität | Spezifität |
|---|---|---|---|---|
| Zellkulturüberstände | ||||
| Serum und Plasma (Heparin | ||||
| EDTA | ||||
| Citrat) und Urin. |
This product is manufactured by Boster Bio and sold through ABMIUM without relabelling.
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Carbonic anhydrase 3 (CA3; carbonic anhydrase III/CA-III) is a cytosolic zinc metalloenzyme with carbonic-anhydrase activity and strong tissue enrichment in skeletal muscle. It is studied in muscle physiology, isozyme-specific CO2 hydration and carbonic-anhydrase expression biology.
Biological function: CA3 catalyses reversible hydration of carbon dioxide using a zinc cofactor. It is distinguished from other carbonic-anhydrase isozymes by tissue-specific expression, including high abundance in skeletal muscle, making it useful for studies of muscle-associated carbonic-anhydrase biology and isozyme kinetics.
