ELISA-Kit geliefert von Boster Bio
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Angiopoietin-2 ist ein Protein, das beim Menschen durch das ANGPT2-Gen kodiert wird. Angiopoietine sind Mitglieder der Familie der vaskulären endothelialen Wachstumsfaktoren und die einzigen bekannten Wachstumsfaktoren, die weitgehend spezifisch für das vaskuläre Endothel sind. ANGPT2 ist ein natürlich vorkommender Antagonist von Angiopoietin-1, der um die Bindung an den TIE2-Rezeptor konkurriert und die ANGPT1-induzierte TIE2-Autophosphorylierung während der Vaskulogenese blockiert. Seine Expression tritt an Orten der vaskulären Umgestaltung auf: Dorsalaorta und wichtige Aortenäste, Eierstock, Plazenta und Gebärmutter.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Sample compatibility evidence using the same validation key.
| Sample type | Probenkompatibilität | Assay-Bereich | Sensitivität | Spezifität |
|---|---|---|---|---|
| Zellkulturüberstände | ||||
| Serum | ||||
| Plasma (Heparin | ||||
| EDTA) | ||||
| Speichel und Muttermilch. |
This product is manufactured by Boster Bio and sold through ABMIUM without relabelling.
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Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
ANGPT2 identifies angiopoietin 2 in Homo sapiens (Human). This target record connects NCBI Gene 285, UniProtKB O15123 and related ABMIUM catalogue products.
Biological function: ANGPT2 (angiopoietin-2) is a secreted vascular ligand that binds TEK/TIE2 and competes with ANGPT1, modulating Tie2 signaling and endothelial stability. Its effects are context-dependent: it can support vascular regression without pro-angiogenic cues and facilitate endothelial migration and proliferation in the presence of VEGF.
