ADAMTS-2 Kaninchen-pAk von ELK Biotechnology
Know who made it. See the evidence. Buy through one marketplace.
ADAMTS-2 Kaninchen-pAk ist ein ELK Biotechnology-Antikörper für Forschungsabläufe, die ADAMTS-2 betreffen.
Dieses Gen kodiert ein Mitglied der ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) Proteinfamilie. Die Mitglieder der Familie teilen mehrere unterschiedliche Proteinmodule, darunter eine Propeptidregion, eine Metalloproteinase-Domäne, eine Disintegrin-ähnliche Domäne und ein Thrombospondin Typ 1 (TS)-Motiv. Einzelne Mitglieder dieser Familie unterscheiden sich in der Anzahl der C-terminalen TS-Motive, und einige besitzen einzigartige C-terminale Domänen. Das kodierte Präproprotein wird proteolytisch prozessiert, um die reife Prokollagen-N-Proteinase zu erzeugen. Diese Proteinase schneidet das N-Propeptid der fibrillären Prokollagene Typ I-III und Typ V ab. Mutationen in diesem Gen verursachen das Ehlers-Danlos-Syndrom Typ VIIC, eine rezessiv vererbte Bindegewebserkrankung. Alternatives Spleißen führt zu mehreren Transkriptvarianten, von denen mindestens eine eine Isoform kodiert, die proteolytisch
| Spezifität | ADAMTS-2 polyklonaler Antikörper detektiert endogene Spiegel von ADAMTS-2 Protein. |
|---|---|
| Nachweisbilder zur Validierung | Western Blot Analyse von HepG2 K562 Hela Colo unter Verwendung von ADAMTS-2 Antikörper. Sekundärantikörper (Katalog-Nr.: RS0002) wurde 1:20000 verdünnt. |
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Arten | WB | IHC | IF | ELISA | IP | FCM | ChIP |
|---|---|---|---|---|---|---|---|
| Mensch | |||||||
| Ratte | |||||||
| Maus |
This product is manufactured by ELK Biotechnology and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
ADAM metallopeptidase with thrombospondin type 1 motif 4 (ADAMTS4/ADAMTS-4), also known as aggrecanase-1, is an extracellular matrix metalloprotease strongly associated with proteoglycan turnover.
Biological function: ADAMTS4, also known as aggrecanase-1, is a secreted ADAMTS-family metalloprotease. Curated NCBI and reviewed UniProt annotations describe cleavage of aggrecan and cartilage oligomeric matrix protein (COMP); NCBI also reports brevican degradation.
